منابع مشابه
611 Butler.qxd
Background. Theoretical and clinical developments suggest that opportunistic interventions could be developed that are more effective and satisfying to use than brief advice to quit smoking. Motivational consulting was influenced by the ‘stages of change’ model, self-efficacy theory, motivational interviewing, and the patient-centred clinical method. Aim. To compare the clinical and cost-effect...
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But which fixed point of Γ do we want? We would like to take the “least” fixed point, in the sense that we want C[[while b do c]] to give a non-⊥ result only when required by the intended semantics. (For example, we want C[[while true do skip]]σ =⊥ for all σ.) The rest of this lecture will expand on this notion of least fixed point, with a look at the underlying theory of partial orders. Iterat...
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Members of the solute carrier (SLC) family of transporters are responsible for the cellular influx of a broad range of endogenous compounds and xenobiotics in multiple tissues. Many of these transporters are highly expressed in the gastrointestinal tract, liver, and kidney and are considered to be of particular importance in governing drug absorption, elimination, and cellular sensitivity of sp...
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Renal metabolism by UDP-glucuronosyltransferase (UGT) enzymes is central to the clearance of many drugs. However, significant discrepancies about the relative abundance and activity of individual UGT enzymes in the normal kidney prevail among reports, whereas glucuronidation in tumoral kidney has not been examined. In this study, we performed an extensive profiling of glucuronidation metabolism...
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Microtia is a congenital malformation of the outer ears. Although both genetic and environmental components have been implicated in microtia, the genetic causes of this innate disorder are poorly understood. Pigs have naturally occurring diseases comparable to those in humans, providing exceptional opportunity to dissect the molecular mechanism of human inherited diseases. Here we first demonst...
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ژورنال
عنوان ژورنال: Acta Crystallographica Section E Structure Reports Online
سال: 2009
ISSN: 1600-5368
DOI: 10.1107/s1600536809053409